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SUMMARY:Modelling and simulation of elastic cells in flow - Aland\, S (Tec
 hnische Universitt Dresden)
DTSTART:20151112T110000Z
DTEND:20151112T123000Z
UID:TALK62398@talks.cam.ac.uk
CONTACT:42080
DESCRIPTION:Accurate measurements of cell elasticity help doctors and biol
 ogists to detect diseases and physiological changes of biological cells. A
 n innovative new technique uses a flow scenario to measure the elasticity 
 of large amounts of cells at a rate of 100 cells per second. The idea is t
 o flow cells through a narrow channel which leads to deformation by shear 
 stress and pressure gradients. A comparison of the observed cell shapes wi
 th numerical simulation results permits conclusions on the elasticity of t
 he cell.\n\nIn my talk I will address numerical methods to simulate this s
 cenario. In particular I will present three different modeling approaches 
 for cells flowing through a narrow channel\, where cells are modeled eithe
 r as\n\n(i) viscous fluids with surface tension to account for actomyosin 
 contraction of the cytoskeleton\,\n(ii) viscoelastic bodies to account for
  the viscoelasticity of intracellular components\,\n(iii) fluid-filled ela
 stic shells accounting for the elasticity of the cytoskeleton.\n\nA phase 
 field is used in all three approaches to represent the cell geometry which
  permits an easy mechanism to couple the cell geometry to additional equat
 ions for elasticity and surface tension. I will compare the obtained cell 
 shapes with experimental and analytical results and draw conclusions on wh
 ich the model is best-suited to describe biological cells in flow.\n
LOCATION:Seminar Room 2\, Newton Institute Gatehouse
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