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SUMMARY:Using computer simulations to understand how epigenetic marks cont
 rol the organisation of the genome at the nanoscale - Rosana Collepardo\, 
 University of Cambridge
DTSTART:20151118T140000Z
DTEND:20151118T150000Z
UID:TALK62525@talks.cam.ac.uk
CONTACT:Lucy Colwell
DESCRIPTION:The three-dimensional organisation of the DNA is one of the gr
 eat marvels of physical biology. By winding around a special class of prot
 eins\, the metre-long DNA manages to compress enormously to fit inside tin
 y (6 μm) nuclei\, avoid entanglement and\, moreover\, maintain exquisite 
 control over the accessibility of the information it carries. The structur
 e of this remarkable complex of DNA and proteins\, known as chromatin\, de
 termines how easy the DNA can be accessed and\, thus\, it is intimately li
 nked to gene expression regulation. However\, chromatin structure and its 
 modulation are not fully understood. In this talk\, I will explain how the
  structure of chromatin is much more fluid and tuneable than originally pr
 oposed\, which explains how chromatin achieves various different roles in 
 vivo according to the transcriptional state\, cell-cycle stage\, or in res
 ponse to environmental signals  (Collepardo and Schlick\, PNAS 2014). I wi
 ll also discuss how multiscale modelling can be used to reveal the molecul
 ar mechanisms behind epigenetic control of chromatin structure and provide
  a link between epigenomes\, structure\, and gene function (Collepardo et 
 al.\, JACS\, 2015).
LOCATION:Dept. of Chemistry\, Wolfson Lecture Theatre
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