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SUMMARY:mRNA stability is substantially dictated by the action of the ribo
 some - Rachel Green\, Johns Hopkins University\, School of Medicine
DTSTART:20160225T103000Z
DTEND:20160225T113000Z
UID:TALK62577@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:There are several mRNA surveillance pathways in eukaryotes (NG
 D\, NSD and NMD) that moderate the effects of natural errors in the cell a
 nd more broadly regulate gene expression. We have previously defined bioch
 emical parameters of the factors Dom34\, Hbs1 and Rli1 and their role on t
 he ribosome in NGD and NSD using our previously developed in vitro reconst
 ituted yeast translation system. We have correlated these biochemical obse
 rvations with ribosome profiling experiments to broadly define the in vivo
  targets of these same mRNA surveillance pathways. We are currently combin
 ing these same approaches to better define the mechanism of action of the 
 translational repressor Dhh1. These studies argue that Dhh1 senses ribosom
 e speed and communicates that information to the mRNA decay machinery such
  that mRNA half lives are correlated with codon optimality.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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