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SUMMARY:A chemical approach to understanding cell division - Ulrike Eggert
DTSTART:20160202T161500Z
DTEND:20160202T171500Z
UID:TALK62586@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:I will focus on our work to understand how membranes and membr
 ane trafficking participate in cytokinesis. Although it is known that memb
 ranes are needed to seal daughter cells after severing\, very little is kn
 own about whether (and how) specific lipids are involved in cytokinesis. M
 assive membrane rearrangements occur during cell division\, suggesting tha
 t lipids play specific roles. We recently used mass spectrometry to determ
 ine if the lipidome changes in dividing cells and at a division site (the 
 midbody) and found that only very specific lipids with specific side chain
 s accumulate (Atilla-Gokcumen\, Muro et al.\, Cell 2014). Using AFM\, we d
 emonstrated differences in the mechanical properties of live dividing cell
 s and their isolated lipids relative to non-dividing cells. In parallel\, 
 we systematically used RNAi to knock down lipid biosynthetic enzymes and i
 dentified enzymes required for division\, which highly correlated with lip
 ids accumulated in dividing cells. Having determined the nature of lipids 
 involved in cell division and their biosynthetic enzymes\, the next steps 
 are to understand their functions. To further investigate the lipids’ bi
 ological roles\, we are using chemical biology and cell biology approaches
 .\n\n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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