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SUMMARY:Single Molecule Enzymology: Transcription against Supercoiling - P
 rof. Xiaoliang Sunny Xie - Mallinckrodt Professor of Chemistry\, Harvard U
 niversity
DTSTART:20160218T160000Z
DTEND:20160218T170000Z
UID:TALK63106@talks.cam.ac.uk
CONTACT:Sharon Connor
DESCRIPTION:Single molecule enzymology has yielded the mechanistic underst
 anding of enzymes both in vitro and in live cells.  Because DNA exists as 
 single molecules that carry genetic codes in an individual cell\, gene exp
 ression is stochastic. Recent single molecule studies of gene expression i
 n live cells have allowed the quantitative description of the central dogm
 a of molecular biology. The molecular mechanism of the ubiquitous phenomen
 on of stochastic transcription\, the burst production of mRNA\, has been r
 evealed by single molecule enzymology.
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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