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SUMMARY:Towards a cure for Alzheimer's Disease - Professor Michele Vendrus
 colo\, Centre for Misfolding Diseases\, Department of Chemistry
DTSTART:20160307T180000Z
DTEND:20160307T190000Z
UID:TALK63111@talks.cam.ac.uk
CONTACT:Beverley Larner
DESCRIPTION:Alzheimer’s disease is the most common cause of dementia. Am
 ong the top ten causes of death worldwide\, this condition is currently th
 e only one that we cannot prevent\, cure or even slow down. In the last tw
 enty years\, great advances have been made in understanding the molecular 
 origins of this disease\, which we now know to be caused by the formation 
 of abnormal protein aggregates in the brain of affected patients. Despite 
 this knowledge\, however\, it has been extremely challenging to identify d
 rugs capable of preventing the formation\, or promoting the removal\, of s
 uch protein aggregates. In this lecture I will describe how recent methodo
 logical advances have led to the discovery of a group of small molecules c
 apable of blocking the first steps in the protein aggregation process. As 
 this type of small molecules could be expected to reduce the risk of Alzhe
 imer’s disease\, they have been called ‘neurostatins’\, in analogy w
 ith statins\, which lower the probability of developing heart conditions.\
 n
LOCATION:Bristol-Myers Squibb Lecture Theatre\, Department of Chemistry
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