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SUMMARY:Chaperoning single proteins - Prof. Sander Tans\, AMOLF
DTSTART:20160127T103000Z
DTEND:20160127T113000Z
UID:TALK64024@talks.cam.ac.uk
CONTACT:Jerome Charmet
DESCRIPTION:Various chaperones are known to bind exposed protein-chains\, 
 and hence protect them from aggregation before folding starts\, and to res
 cue them when they are misfolded. Using optical tweezers\, we explore how 
 chaperones affect the folding of single proteins. We show that various cha
 perones interact with folded protein structures\, and hence actively help 
 solve their conformational search for the native state. They exploit diver
 se mechanisms\, ranging from stimulating local folding to ATP-driven captu
 re and release of partially folded protein structures. The results indicat
 e that chaperones perform more intricate tasks than previously assumed\, a
 nd bring a new perspective to the protein-folding problem
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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