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SUMMARY:Tradeoffs between fast growth and adaptability shape microbial phe
 notypes - Dr Markus Basan\, ETH Zurich
DTSTART:20160201T094500Z
DTEND:20160201T102500Z
UID:TALK64205@talks.cam.ac.uk
CONTACT:Leona Hope-Coles
DESCRIPTION:Microorganisms exhibit a striking diversity of phenotypes in d
 ifferent conditions. Changes in growth rates are accompanied by large vari
 ations in metabolic strategies\, gene expression and cell size. However\, 
 the molecular basis and underlying rationale of many of these complex patt
 erns remains poorly understood. We illustrate how a quantitative approach\
 , based on establishing empirical relations between cellular phenotypes\, 
 can help to elucidate such questions by focusing on two long-standing biol
 ogical problems: the origin of overflow metabolism and the emergence of se
 vere\, multi-hour lag phases. Coarse-grained models yield a quantitative a
 nd predictive understanding of phenotypic patterns under environmental as 
 well as genetic perturbations and can even shed light on underlying molecu
 lar mechanisms. A common theme that emerges is the existence of fundamenta
 l tradeoffs between fast growth and the ability to swiftly adapt to enviro
 nmental changes or stress conditions.
LOCATION:Rayleigh Seminar Room\, Maxwell Centre\, Cavendish Laboratory
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