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SUMMARY:Predefined or Random? Investigating the site of daughter centriole
  formation on the mother centriole using live two-colour fluorescence micr
 oscopy. - Neil Cunningham
DTSTART:20160306T144500Z
DTEND:20160306T150500Z
UID:TALK64922@talks.cam.ac.uk
CONTACT:Andrew Carlotti
DESCRIPTION:The centrosome is the major microtubule-organising centre in a
 nimal cells and as their name suggests\, they have been regarded as playin
 g a central role in many aspects of cellular organisation and morphology s
 uch as cell shape\, polarity and cell division. Cells begin the cell cycle
  with exactly one centrosome which is composed of a pair of orthogonal\, c
 ylindrical centrioles (termed the mother and daughter centriole) surrounde
 d by an amorphous protein mass called the pericentriolar material (PCM). S
 pecifying a single site on the mother centriole for the formation of the d
 aughter centriole is essential to avoid the growth of multiple daughters\,
  which leads to centrosome overduplication and will ultimately result in a
 neuploidy and tumourgenesis. Some questions remain unanswered\; does the d
 aughter centriole form at a specific predefined location on the mother cen
 triole? If so\, what defines this site? Or does the daughter centriole gro
 w out randomly from any side of the mother centriole? In this work\, I att
 empt to address and uncover the answers to some of these questions using l
 ive cell imaging in Drosophila embryos. The results of which will help us 
 understand how normal centriole duplication is regulated.
LOCATION:Winstanley Lecture Theatre
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