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SUMMARY:Inherent variability in the kinetics of amyloid fibril formation -
  Rosalind Allen (University of Edinburgh)
DTSTART:20160405T080000Z
DTEND:20160405T084500Z
UID:TALK65300@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:Co-authors:&nbsp\;Juraj Szavits-Nossan\, Kym Eden\, Ryan Morri
 s\, Martin Evans and Cait MacPhee<br><br>In small volumes\, the kinetics o
 f filamentous protein self-assembly is expected to show significant variab
 ility\, arising from intrinsic molecular noise. We introduce a simple stoc
 hastic model including nucleation and autocatalytic growth via elongation 
 and fragmentation\, which allows us to predict the effects of molecular no
 ise on the kinetics of autocatalytic self-assembly. We derive an analytic 
 expression for the lag-time distribution\, which agrees well with experime
 ntal results for the fibrillation of bovine insulin. Our analysis shows th
 at significant lag-time variability can arise from both primary nucleation
  and from autocatalytic growth and should provide a way to extract mechani
 stic information on early-stage aggregation from small-volume experiments.
LOCATION:Seminar Room 1\, Newton Institute
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