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SUMMARY:Local adaptation in humans: lessons from modern and ancient genome
 s - Dr Aida Andrés\, Max Planck Institute for Evolutionary Anthropology\,
  Leipzig
DTSTART:20160525T153000Z
DTEND:20160525T163000Z
UID:TALK65323@talks.cam.ac.uk
CONTACT:Aurélien Mounier
DESCRIPTION:Our species has reached virtually every corner of the globe\, 
 with human populations settling in geographic areas that are extremely dif
 ferent in ecological terms. The colonization was accompanied by pressure t
 o adapt to the new environments\, and I will present some of our efforts t
 o understand these local adaptations. Analyzing the genomes of present-day
  and early modern humans we observe that positive selection has fundamenta
 lly influenced the (otherwise modest) genetic differences that exist among
  human populations today. We infer that early hunter-gatherers have contri
 buted more genic adaptive alleles than early farmers to present-day Europe
 ans. The ultimate origin of the adaptive alleles remains debated\, with ne
 w\, introgressed\, and neutral standing alleles being plausible sources. I
  will discuss the possibility that shifts in natural selection on previous
 ly non-neutral standing alleles (e.g. slightly advantageous or under balan
 cing selection) mediates fast adaptations to novel environments\, and how 
 these models can help understand human local adaptation.
LOCATION:BioAnth Lecture Theatre (Room 41)\, Division of Biological Anthro
 pology\, Pembroke Street\, Cambridge\, CB2 3QG
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