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SUMMARY:Exact and approximate solutions for spatial stochastic models of b
 iochemical systems - Ramon Grima (University of Edinburgh)
DTSTART:20160620T150000Z
DTEND:20160620T154500Z
UID:TALK66522@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:<span>Co-authors: Claudia Cianci (University of  Edinburgh)\, 
 Stephen Smith (University of Edinburgh) <br></span> <br>Stochastic effects
  in chemical reaction systems have been mostly studied via  the chemical m
 aster equation\, a non-spatial discrete stochastic formulation of  chemica
 l kinetics which assumes well-mixing and point-like interactions between  
 molecules. These assumptions are in direct contrast with what experiments 
 tells  us about the nature of the intracellular environment\, namely that 
 diffusion  plays a fundamental role in intracellular dynamics and that the
  environment  itself is highly non-dilute (or crowded). I will here descri
 be our recent work  on obtaining (i) exact expressions for the solution of
  the reaction-diffusion  master equation (RDME) and its crowded counterpar
 t (cRDME) in equilibrium  conditions and (ii) approximate expressions for 
 the moments in non-equilibrium  conditions. The solutions portray an emerg
 ing picture of the combined influence  of diffusion and crowding on the st
 ochastic properties of chemical reaction  networks. <br><br>Related Links 
 <ul> <li><a target="_blank" rel="nofollow">http://grimagroup.bio.ed.ac.uk/
 index.html</a></li></ul>
LOCATION:Seminar Room 1\, Newton Institute
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