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SUMMARY:Noise Attenuation during the Development of Spatial Pattern - Lei 
 Zhang (Peking University)
DTSTART:20160623T134500Z
DTEND:20160623T143000Z
UID:TALK66556@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:<span>Co-author: Qing Nie (UC Irvine) <br></span> <span><br>Mo
 rphogens provide positional information for spatial patterns of gene  expr
 ession during development. However\, stochastic effects such as local  flu
 ctuations in morphogen concentration and noise in signal transduction make
  it  difficult for cells to respond to their positions accurately enough t
 o generate  sharp boundaries between gene expression domains. In this talk
 \, I will present a  novel noise attenuation mechanism during the developm
 ent of spatial pattern.  First\, we investigate the boundary sharpening in
  the zebrafish hindbrain.  Computational analyses of spatial stochastic mo
 dels show\, surprisingly\, that a  combination of noise in RA concentratio
 n and noise in hoxb1a/krox20 expression  promotes sharpening of boundaries
  between adjacent segments. Second\, we  integrate spatial and temporal no
 ise attenuation in the BMP-FGF signaling  network in the dorsal telencepha
 lon. We demonstrate that perturbing FGF  signaling transiently will lead t
 o a noisier boundary with loss of boundary s  harpness and a global delay 
 in development.</span>
LOCATION:Seminar Room 1\, Newton Institute
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