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SUMMARY:Biomimicry with Synthetic Receptors: Self-Assembly and Molecular R
 ecognition - Richard Hooley\, University of California
DTSTART:20170216T140000Z
DTEND:20170216T150000Z
UID:TALK66802@talks.cam.ac.uk
CONTACT:Sharon Connor
DESCRIPTION:The focus of our research is towards novel multicomponent self
 -assembly and molecular recognition processes. This research centers on co
 ntrolling the interior space of self-assembled metal ligand complexes in o
 rder to mimic the behavior of enzyme active sites in a purely synthetic en
 vironment. Appending functional groups to the cage interiors allows contro
 l of self-assembly processes including stereocontrol at metal centers\, li
 gand self-sorting and chemical reactivity. In addition\, the presence of r
 eactive functional groups allows post-synthetic modification of sensitive 
 cage structures. \n\nIn addition\, we have shown that water-soluble deep c
 avitands (small molecules capable of selective aqueous molecular recogniti
 on) can be incorporated into membrane bilayers assembled onto a nanoglassi
 fied surface. The receptors retain their selective host properties\, and r
 eal-time analysis via surface plasmon resonance and fluorescence microscop
 y is possible. These receptors have applications in biorecognition and sen
 sing in biomimetic membranes and living cells\, as well as the ability to 
 direct nanoscale synthesis at the bilayer:water interface.\n\n
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry
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