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SUMMARY:Health Economics @ Cambridge seminar: Is it cost-effective to scre
 en women for abdominal aortic aneurysm? Results from the Screening Women f
 or AAA (SWAN) project - Dr Mike Sweeting\, Cadiovascular Epidemiology Unit
 \, University of Cambridge
DTSTART:20170619T140000Z
DTEND:20170619T150000Z
UID:TALK67030@talks.cam.ac.uk
CONTACT:Ed Wilson
DESCRIPTION:The NHS Abdominal Aortic Aneurysm (AAA) screening programme (N
 AAASP) was initiated in 2009 and invites men aged 65 in the UK to screenin
 g. The programme was initiated following the completion of the large Multi
 centre Aneurysm Screening Study randomised controlled trial and subsequent
  health economic modelling\, which showed population screening for men to 
 be highly cost-effective. AAA screening in women has\, until now\, not bee
 n considered worthwhile since the prevalence of AAA (aortic diameter ≥3.
 0cm) in women is substantially lower than in men. However\, previous model
 ling has suggested that NAAASP would still be cost-effective in men even d
 own to an AAA prevalence of 0.35%. Moreover\, one-third of deaths from AAA
  in the UK are now in women. Hence the cost-effectiveness of AAA screening
  women needs to be formally assessed.\n\nIn this talk I will describe the 
 Screening Women for Abdominal Aortic Aneurysm (SWAN) project\, where we un
 dertook a health economic assessment of AAA screening in women. A previous
  multi-state model of AAA screening in men was adapted to create a more fl
 exible discrete event simulation (DES) model. Information from published l
 iterature or relevant databases was used to obtain input parameters for th
 is model relevant to women. \n\nI will describe how the DES model was deve
 loped to allow the progression of AAA to be modelled continuously using a 
 mixed-effects growth model of aortic diameter. This allowed individuals to
  grow at different rates and for different surveillance\, diagnosis and in
 tervention strategies based on observed diameter measurements to be easily
  compared. Monte Carlo error in the estimation of incremental costs and ef
 fects was reduced using two complementary approaches\; firstly we simulate
 d pairs of “twins” with similar characteristics\, one invited to scree
 ning and one not\; and secondly we oversampled individuals who have an AAA
  at screening.\n\nFinally\, based on findings from this project I will add
 ress whether population AAA screening in women is likely to be cost-effect
 ive and provide recommendations for researchers wishing to conduct their o
 wn DES modelling.\n
LOCATION:Small Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
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