BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:The psychological and neural basis of the individual vulnerability to compulsive disorders: new insights from preclinical studies. - Dr Davi d Belin DTSTART:20161007T153000Z DTEND:20161007T170000Z UID:TALK67480@talks.cam.ac.uk CONTACT:Louise White DESCRIPTION:Drug addiction results from the interaction between a vulnerab le individual\, a drug and an environment which interactions and their con tribution to the transition from volitional to compulsive drug seeking hab its\, the hallmark of addiction\, are yet to be understood. However\, over the last decade the development of novel preclinical models of addiction in rodents\, factoring in the notion of inter-individual differences with the operationalisation of the main clinical features of addiction in human s have helped shed a new light on the mechanisms subserving this inter-ind ividual vulnerability to develop compulsive drug seeking habits. Dr. Belin will review the psychological constructs of the most recent preclinical m odels of addiction and investigate the recent breakthrough in the psycholo gical and neural substrates of the propensity to use drugs and to switch f rom controlled drug use to maladaptive drug seeking habits.\nIn this proce ss\, Dr. Belin will especially discuss the role of dynamic functional shif ts within the corticostriatal circuits that subserve the development of dr ug seeking \n\nBio\nD. Belin graduated in 2005 in Neuroscience and Neuroph armacology at the University of Bordeaux 2 in France. During his PhD he de veloped the first preclinical model of cocaine addiction based in the oper ationalization of multiple clinical criteria of the pathology as defined i n humans.\nHe then moved the laboratory of Pr Barry Everitt at the Departm ent of Experimental Psychology of the University of Cambridge in January 2 006. With his mentor he investigated the corticostriatal mechanisms of coc aine seeking habits and the relationships between impulsivity and compulsi ve cocaine self-administration\, leading to a breakthrough in our understa nding of the neurological and psychological bases of individual vulnerabil ity to cocaine addiction.\nIn 2009 he tenured at the INSERM and establishe d his INSERM laboratory in Poitiers\, France. In July 2011 he was distingu ished with the Habilitation to Direct Research\, the highest academic degr ee delivered in France. His INSERM team research program was ranked first during the national evaluation of the INSERM in 2012. It focused on the ps ychological\, neural and cellular mechanisms of individual vulnerability t o compulsive disorders and their modulation by the environment. \nWhile in France D. Belin also developed a European INSERM Associated laboratory wi th Pr Barry Everitt’s lab thereby pursuing a common research program on the corticostriatal mechanisms of addiction to various classes of drugs.\n In October 2013 D. Belin returned to Cambridge as a Lecturer in Neuroscien ce at the Department of Pharmacology. There he established his laboratory focusing on the neuropsychopharmacology of compulsive disorders. \nIn Octo ber 2016\, D. Belin will move to the Department of Psychology where he wil l consolidate his laboratory focusing on the psychobiology of compulsive d isorders.\nOver the last ten years D. Belin has authored 40 publications a nd 12 book chapters and edited the Intech Book "Drug Addictions: from path ophysiology to treatment".\nD. Belin is a former Fellow of Emmanuel Colleg e\, Cambridge\, and has received the Mémain-Pelletier Award from the Fren ch Academy of Science and the Young Investigator Award from the European B ehavioural Pharmacology Society. In 2015 he was elected one of the first 2 0 fellows of the FENS-Kavli network of Excellence (http://www.fens.org/Out reach/FENS-Kavli-Network-of-Excellence/).\n LOCATION:Ground Floor Lecture Theatre\, Department of Psychology END:VEVENT END:VCALENDAR