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SUMMARY:Comparative population genomics in animals: genetic diversity\, ad
 aptive rate\, species barrier  - Dr Nicolas Galtier\, University of Montpe
 llier 
DTSTART:20170126T140000Z
DTEND:20170126T150000Z
UID:TALK69053@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:High-throughput sequencing technologies offer the opportunity 
 to investigate molecular variation at the genomic scale in non-model organ
 isms. We have sequenced full mRNA extracts in >400 individuals from >80 ta
 xonomically diverse species of animals with the goal of linking population
  genomic patterns to species biology and ecology. Three major results will
  be presented: [1] the genetic diversity of a species is surprisingly well
  predicted by life-history traits\, such as longevity and amount of parent
 al care\, with no detectable impact of the geographic range\; [2] unlike t
 he efficiency of purifying selection\, the rate of adaptive amino-acid evo
 lution is not correlated to species effective population size\, suggesting
  that adaptation is not limited by the supply of new mutations\; [3] the a
 bility of two populations/species to effectively exchange migrant is well 
 predicted by the genome-average net molecular divergence\, d\; the "grey z
 one" of speciation is as narrow as one order of magnitude of d and include
 s many semi-isolated gene pools\, between which gene flow is restricted to
  a portion of the genome. The implications of these results for molecular 
 evolutionary and conservation genetic research will be discussed.\n\nRefer
 ences:\n\n[1] Romiguier J.\, Gayral P.\, Ballenghien M.\, Bernard A.\, Cah
 ais V.\, Chenuil A.\, Chiari Y.\, Dernat R.\, Duret L.\, Faivre N.\, Loire
  E.\, Lourenco J.M.\, Nabholz B.\, Roux C.\, Tsagkogeorga G.\, Weber A.\, 
 Weinert L.A.\, Belkhir K.\, Bierne N.\, Glémin S. & Galtier N. 2014. Comp
 arative population genomics in animals uncovers the determinants of geneti
 c diversity. Nature 515:261-263. \n\n[2] Galtier N. 2016. Adaptive protein
  evolution in animals and the effective population size hypothesis. PLoS G
 enetics 12:e1005774.\n\n[3] Roux C.\, Fraisse C.\, Romiguier J.\, Anciaux 
 Y. \, Galtier N.\, Bierne N. 2016. Shedding light on the grey zone of spec
 iation along a continuum of genomic divergence. PLoS Biology 14: e2000234.
 \n\n
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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