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SUMMARY:Toll Receptors - Dr Nick Gay\, Department of Biochemistry\, Univer
 sity of Cambridge
DTSTART:20070425T153000Z
DTEND:20070425T163000Z
UID:TALK6952@talks.cam.ac.uk
CONTACT:5684
DESCRIPTION:TLRs are single pass transmembrane receptors and are activated
  by a variety of stimuli derived from microbes. The mechanism of signal tr
 ansduction involves stimulus induced dimerization of two receptor chains. 
 Dimerization appears to involve concerted protein conformational changes a
 nd cooperativity which generate a specific cytoplasmic protein scaffold th
 at supports downstream signalling events. I will present recent data about
  he molecular nature of this signalling process and evidence for complex c
 rosstalk with other signalling pathways such as those of PKC.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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