BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Lambda Display Phage as a Mucosal Vaccine Delivery Vehicle for Pep
 tide Antigens - Professor Sidney Hayes and Dr Philip J. Griebel\, Universi
 ty of Saskatchewan\, Saskatoon\, Canada
DTSTART:20170119T154500Z
DTEND:20170119T161500Z
UID:TALK69700@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:There is increasing interest in using bacteriophage as protein
 /peptide and DNA vaccine delivery vehicles. Little isn known\, however\, a
 bout their capacity to induce mucosal immune responses in the small intest
 ine. Targetted delivery of of lambda phage (LP) to specific sites in the s
 mall intestine of newborn calves confirmed LP were immunpgenic and we re s
 pecifically taken up by mucosa-associated lymphoid tissues\, including Pey
 er's patches. A lambda display phage (LDP) was then used to confirm that s
 pecific IgA antibody responses were induced to the display peptide. This s
 pecific antibody response was observed in the absence of an adjuvant or ex
 ogenous immune stimulating compound. Therefore\, we conclude that LDP may 
 be used as oral vaccine delivery vehicle.  
LOCATION:Online
END:VEVENT
END:VCALENDAR