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SUMMARY:Intrinsic and extrinsic determinants of pancreatic cancer stem cel
 ls  - Professor Christopher Heeschen\, Queen Mary University of London\, L
 ondon\, United Kingdom
DTSTART:20170208T093000Z
DTEND:20170208T100000Z
UID:TALK69754@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Apart from functioning as a mechanical barrier and providing s
 tructural support for tumour growth and development\, the tumour microenvi
 ronement (TME) mostly constitutes a dynamic heterogeneous cell compartment
  that provides an important niche for the embedded cancer (stem) cells. Wh
 ile it has been shown conclusively that cancer stem cells (CSC) bear cell-
 intrinsic stemness features\, they are also a product of their relationshi
 p with the TME\, promoting their aggressiveness including metastasis and d
 rug resistance. Therefore\, we are developing ex vivo 3D models that faith
 fully resemble the in vivo tumour biology and allow us to study CSC in a c
 omprehensive TME.   
LOCATION:Online
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