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SUMMARY:ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease - Dr. 
 Ta Yuan Chang\, Geisel School of Medicine at Dartmouth\, Hanover\, United 
 States
DTSTART:20170223T153000Z
DTEND:20170223T160000Z
UID:TALK69831@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Late onset Alzheimer’s disease (LOAD) is the most prevalent 
 form of dementia\, and it has no cure at present. Cholesterol metabolism i
 s closely associated with AD at several stages. Cholesterol ester (CE) is 
 the storage form of cholesterol. A causal relationship exists between LOAD
  and increased CE content in the brain. Acyl-CoA:cholesterol acyltransfera
 se 1 (ACAT1) converts free cholesterol to cholesteryl esters in various ti
 ssues including the brain. Here I review the recent evidence that implicat
 es ACAT1 as a potential therapeutic target for AD. I also discuss the pote
 ntial usage of various ACAT inhibitors currently available to treat AD.
LOCATION:Online
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