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SUMMARY:The role of Chrisanthemum virus B p12 in the regulation of plant t
 ranscription and supression of RNA silencing. - Nina Lukhovitskaya\, Carr 
 Group
DTSTART:20170126T130000Z
DTEND:20170126T133000Z
UID:TALK69932@talks.cam.ac.uk
CONTACT:42122
DESCRIPTION:Recent studies have uncovered numerous nucleus-localized prote
 ins encoded by plant RNA viruses. Whereas for some of these viruses nuclea
 r (or\, more specifically\, nucleolar) passage of the proteins is needed f
 or the virus movement within the plant or suppression of host defense\, th
 e nuclear function of these proteins remains largely unknown. The situatio
 n has been clarified for one group of plant RNA viruses\, the Carlaviruses
 . Being positive-stranded RNA viruses\, carlaviruses multiply exclusively 
 in the cytoplasm. Chrysanthemum virus B (CVB\, a carlavirus) encodes a zin
 c-finger protein p12 targeted to the nucleus in a nuclear localization sig
 nal-dependent manner. p12 directly interacts with chromatin and plant prom
 oters\, thus\, acts as a eukaryotic transcription factor (TF) and activate
 s expression of a host TF involved in regulation of cell size and prolifer
 ation to favor virus infection. Therefore\, our studies identified a novel
  nuclear stage in CVB infection involving modulation of host gene expressi
 on and plant development. Whereas it is well established that any RNA viru
 s actively replicating in the cell causes changes in the transcriptome\, o
 ur study expanded this view by showing that some positive-stranded RNA vir
 uses can directly manipulate host transcription by encoding eukaryotic TFs
 .\n\nViral suppressors of RNA silencing (VSRs) are critical for the succes
 s of virus infection and efficient accumulation of virus progeny. In addit
 ion to its TF function the p12 protein suppresses RNA silencing. Moreover\
 , p12 counter-silencing activity can be uncoupled from its function as a t
 ranscription factor in the nucleus. 
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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