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SUMMARY:Using synthetic biology in algae for the production of designer li
 pids - Katrin Geisler\, Smith Group
DTSTART:20170323T130000Z
DTEND:20170323T133000Z
UID:TALK69937@talks.cam.ac.uk
CONTACT:42122
DESCRIPTION:The research focus on microalgae as biotechnological hosts has
  increased enormously over the past few years. The aim of the BBSRC-funded
  'Algal Oils by Design' project is to engineer microalgae to produce in a 
 predictable fashion high levels of novel fatty acids or valuable oils\, su
 ch as the nutritionally important omega-3 fatty acids. The marine diatom P
 haeodactylum tricornutum is an interesting biotechnology host because of t
 he ability to reach a high biomass\, the natural accumulation of large amo
 unts of lipids and the availability of genomic resources. However\, there 
 are still limitations for a wider commercial use and one bottleneck for th
 e development of commercial usable strains is the availability of a variet
 y of molecular biology tools to allow controlled transgene expression. My 
 role in this collaboration is to follow a synthetic biology approach and t
 est the functionality of various DNA parts\, such as promoters\, 5’UTRs\
 , 3’UTRs and chloroplast target peptides for Phaeodactylum tricornutum. 
 I will present data on the influence of different promoter and terminator 
 combinations on transgene expression. In the future the characterised DNA 
 parts will be used to modify the lipid metabolism in Phaeodactylum and fol
 lowing microdroplet cell sorting and lipid analysis of transformants by co
 llaborating labs\, the data obtained will be fed into metabolic models tha
 t can inform the rational design of future cell lines to produce different
  high-value oils.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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