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SUMMARY:Sulfur Chemistry for Biology and the Environment - Dr Justin Chalk
 er
DTSTART:20170713T110000Z
DTEND:20170713T120000Z
UID:TALK70410@talks.cam.ac.uk
CONTACT:48618
DESCRIPTION:This lecture will describe two ways in which our lab has used 
 novel sulfur chemistry to create tools useful for biochemistry and environ
 mental health. In the first part of the presentation\, the chemistry of cy
 steine will be examined\, with reference to both natural and synthetic sys
 tems. The study of post-translational modification of proteins will be fea
 tured as well as general strategy to mutate proteins directly using select
 ive chemistry. These “chemical mutations” bypass the central dogma and
  allow the construction of proteins bearing glycosylation\, phosphorylatio
 n\, and methylation that are otherwise difficult to access using tradition
 al biochemistry.\nIn the second part of the lecture\, applications of new 
 high sulfur content polymers will be presented. By employing readily avail
 able elemental sulfur as a starting material\, a variety of inexpensive an
 d functional polysulfides can be prepared entirely from industrial waste. 
 Application of these sulfur polymers in mercury remediation and oil spill 
 cleanup will be discussed.  We will also detail our efforts to address the
  widespread impact of mercury pollution due to artisanal gold mining. This
  practice compromises the health of 15 million miners involved in this act
 ivity—the largest source of mercury emissions on the planet.\n\n\nChalke
 r\, J.M.\; Lercher\, L.\; Rose\, N.R.\; Schofield\, C.J.\; Davis\, B.G. An
 gew. Chem. Int. Ed. 2012\, 51\, 1835-1839.\n\nWright\, T. H.\; Bower\, B. 
 J.\; Chalker\, J. M.\; Bernardes\, G. J. L.\; Wiewiora\, R.\; Ng\, W.-L.\;
  Raj\, R.\; Faulkner\, S.\; Vallée M. R. J.\; Phanumartwiwath\, A.\; Cole
 man\, O. D.\; Thézénas\, M.-L.\; Khan\, M.\; Galan\, S. R. G.\; Lercher\
 , L.\; Schombs\, M. W.\; Gerstberger\, S.\; Palm-Espling\, M. E.\; Baldwin
 \, A. J.\; Kessler\, B. M.\; Claridge\, T. D. W.\; Mohammed\, S.\; Davis B
 . G. Science 2016\, 2016\, 354\, aag1465. DOI: 10.1126/science.aag1465\n\
 nCrockett\, M. P.\; Evans\, A. M.\; Worthington\, M. J. H.\; Albuquerque\,
  I. S.\; Slattery\, A. D.\; Gibson\, C. T.\; Campbell\, J. A.\; Lewis\, D.
 A.\; Bernardes\, G. J. L.\; Chalker\, J. M. Angew. Chem. Int. Ed. 2016\, 5
 5\, 1714-1718.\n\nWorthington\, M. J. H.\; Kucera\, R. L.\; Chalker\, J. M
 . Green Chem. 2017\, 19\, 2748-2761.
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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