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SUMMARY:Disease Migration - Professor Eva Harris\, University of Californi
 a\, Berkeley
DTSTART:20180216T173000Z
DTEND:20180216T183000Z
UID:TALK71617@talks.cam.ac.uk
CONTACT:Janet Gibson
DESCRIPTION:Dengue and Zika are mosquito-borne viral diseases that consitu
 te major public health and medical problems worldwide. Dengue has been a s
 courge for decades and only continues to increase in magnitude\, geographi
 c distribution\, and severity\, whereas Zika recently took the world by su
 rprise with a dramatic epidemic in the Americas that was linked to severe 
 congenital defects\, including microcephaly\, when infection occurred duri
 ng pregnancy. In this lecture\, “Migration of dengue and Zika viruses: A
 cross continents\, around cities\, and within the human host”\, we will 
 explore the concept of “migration” as applied to dengue and Zika on mu
 ltiple levels. First\, we will examine the emergence and spread of these v
 iruses seen through both epidemiological and phylogenetic lenses\, through
  studies of human populations and viral sequences. Next\, we will focus on
  spatial studies of dengue and Zika transmission in our cohort study of ch
 ildren in Managua\, Nicaragua\, where we have observed differences in Zika
  virus transmission at a hyper local level\, allowing identification of ho
 t-spots and environmental risk factors. Finally\, we will turn to “migra
 tion” of dengue and Zika viruses within the human body\, via studies of 
 intrahost diversity of these RNA viral sequences in different bodily compa
 rtments as well as visualization of Zika virus invasion of the human place
 nta. Through this unusual interpretation of the concept of migration\, we 
 hope to introduce multiple themes in research and public health of these i
 mportant human infectious diseases.\n\nBiography\n\nDr. Eva Harris is a Pr
 ofessor in the Division of Infectious Diseases and Vaccinology in the Scho
 ol of Public Health\, Director of the Center for Global Public Health\, an
 d Chair of the Infectious Diseases and Immunity Graduate Group at the Univ
 ersity of California\, Berkeley. She has developed multidisciplinary appro
 aches to study the virology\, pathogenesis\, immunology\, epidemiology\, c
 linical aspects\, and control of dengue\, Zika\, and chikungunya\, the mos
 t prevalent mosquito-borne viral diseases in humans. Specifially\, her res
 earch addresses immune correlates of protection and pathogenesis\, viral a
 nd host factors that modulate disease severity\, and virus replication and
  evolution\, using in vitro approaches\, animal models\, and observational
  studies involving human populations. This has been achieved through her r
 esearch program at UC Berkeley and in Nicaragua and other endemic Latin Am
 erican countries\, where she has worked extensively for almost 30 years. I
 n 1997\, she received a MacArthur Award for work over the previous ten yea
 rs developing programs to build scientific capacity in developing countrie
 s to address public health and infectious disease issues. This enabled her
  to found a non-profit organization in 1998\, Sustainable Sciences Institu
 te (SSI\; www.sustainablesciences.org)\, with offices in San Francisco\, N
 icaragua\, and Egypt\, which works to improve public health in developing 
 countries by building local capacity for scientific research on priority d
 iseases. Dr. Harris was named a Pew Scholar for her work on dengue pathoge
 nesis. She received a national recognition award from the Minister of Heal
 th of Nicaragua for her contribution to scientific development and was sel
 ected as a “Global Leader for Tomorrow” by the World Economic Forum. S
 he has published over 240 peer-reviewed articles\, as well as a book on he
 r international scientific work.
LOCATION:LMH\, Lady Mitchell Hall
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