BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:In the trenches of systems medicine: Genomic risk scores and new b iomarkers - Professor Michael Inouye\, Centre for Systems Genomics\, Unive rsity of Melbourne DTSTART:20170321T120000Z DTEND:20170321T130000Z UID:TALK71680@talks.cam.ac.uk CONTACT:48007 DESCRIPTION:While major advances have been made in using genomics for the clinical management of rare diseases and cancers\, for many common disease s genomics plays a lesser yet still important role in aetiology. In this s etting\, genomic risk may useful for primary prevention where individuals are knowledgeable of their genetic predisposition\, aware of how risk vari es over time with biomarkers and lifestyle\, and amenable to interventions which minimise modifiable risk factors. Toward this end\, I will present recent work in quantifying genomic risk for various common diseases\, incl uding celiac disease and coronary heart disease\, and in making genomic ri sk scores useful in risk management and subsequent diagnosis. To capture t he time-varying component of disease risk we aim to integrate multiple omi cs layers to identify and characterise new biomarkers as well as construct multi-omic disease predictors. Here\, I'll present recent work in using o mics data to map the blood metabolomic-transcriptomic interface as well as reveal the anti-microbial response associated with GlycA\, an NMR-derived biomarker for severe infection and sepsis. Finally\, using cohorts with m etabolomics data and linked health-records\, the GlycA NMR signal can be d econvoluted to identify the glycoprotein(s) which predictive specific caus es of future hospitalisation and death. \n\n\nThis talk will be chaired by Dr Dirk Paul\, University Lecturer in Integrative Human Genomics\, Cardio vascular Epidemiology Unit\n\n LOCATION:Seminar Room\, Department of Public Health and Primary Care\, Str angeways Research Laboratory\, Worts Causeway CB18RN END:VEVENT END:VCALENDAR