BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Distinct tensile and adhesive forces determine germ layer organiza
 tion during gastrulation - Dr Carl Philipp Heisenberg\, Max-Planck-Institu
 te for Molecular Cell Biology and Genetics\, Dresden\nGermany
DTSTART:20070509T120000Z
DTEND:20070509T130000Z
UID:TALK7189@talks.cam.ac.uk
CONTACT:Jurij Kotar
DESCRIPTION:Understanding the factors that produce tissue organization dur
 ing development is one of the most fundamental goals in developmental biol
 ogy. Various scenarios have been proposed in order to explain cell sorting
  and tissue organization on the basis of the differential properties and b
 ehaviors of the constituent cells. However\, validating these scenarios ha
 s been notoriously difficult due to the lack of appropriate tools needed t
 o simultaneously measure the relevant parameters. Here we show that by usi
 ng a combination of single cell force spectroscopy\, tissue culture and in
  vivo transplantation experiments\, we are able to quantify the specific a
 dhesive and mechanical properties of the different germ layer progenitors 
 from gastrulating zebrafish embryos. With these values in hand\, we propos
 e a coherent scenario that accurately predicts germ layer organization dur
 ing zebrafish gastrulation.
LOCATION:IRC in Superconductivity Seminar Room\, Cavendish Laboratory
END:VEVENT
END:VCALENDAR