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SUMMARY:Paul Bergen: Ordered export of proteins to build a bacterial cell 
 surface nanomachine - Paul M Bergen\, Department of Pathology
DTSTART:20170614T150000Z
DTEND:20170614T160000Z
UID:TALK72763@talks.cam.ac.uk
CONTACT:Charlotte Askew
DESCRIPTION:Bacteria build rotary nanomachines\, called flagella\, on thei
 r cell surface to move through their environment. Their assembly requires 
 thousands of subunits to be exported across the cell membrane by dedicated
  type III export machinery. Assembly is biphasic\, with subunits for the f
 ilament only exported once the rod and hook structures are mature. The ord
 er of subunit export is imposed by the FlhB1 export gate and by the molecu
 lar ruler\, FliK2. I will describe how FliK triggers the export specificit
 y switch by promoting a radical conformational change in FlhB.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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