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SUMMARY:Satellite RNAs\, Heterochromatin and Cancer: A Novel Mechanism of 
 Induction of Breast Cancer by Loss of BRCA1? - Professor Inder Verma\, Sal
 k Institute\, San Diego\, USA 
DTSTART:20170626T140000Z
DTEND:20170626T150000Z
UID:TALK72854@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:*Abstract:*\n\nHeterochromatic repetitive satellite RNAs are e
 xtensively transcribed in a variety of human cancers\, including BRCA1-mut
 ant breast cancer. Aberrant expression of satellite RNAs in cultured cells
  induces the DNA damage response\, activates cell cycle checkpoints\, and 
 causes defects in chromosome segregation. However\, the mechanism by which
  satellite RNA expression leads to genomic instability is not well underst
 ood. We have demonstrated  that increased levels of satellite RNAs in mamm
 ary glands induce tumor formation in mice. Using mass spectrometry\, one c
 an further show that genomic instability induced by satellite RNAs occurs 
 through interactions with BRCA1-associated protein networks required for t
 he stabilization of DNA replication forks. Additionally\,  formation of RN
 A-DNA hybrid contributes to DNA replication defects in cells expressing sa
 tellite RNAs. These studies lay the foundation for developing novel therap
 eutic strategies that block the effects of non-coding satellite RNAs in ca
 ncer cells.
LOCATION:Clifford Albutt Lecture theatre\, Clinical School
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