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SUMMARY:How to read and write mechanical information in DNA molecules - pr
 of. dr. Helmut Schiessel\, University of Leiden
DTSTART:20170616T150000Z
DTEND:20170616T160000Z
UID:TALK72960@talks.cam.ac.uk
CONTACT:Otti Croze
DESCRIPTION:DNA molecules contain a second layer of information on top of 
 the \nclassical genetic information. This second layer is \ngeometrical/me
 chanical in nature and guides the folding of DNA molecules \ninside cells.
  With the help of a new Monte Carlo technique\, Mutation \nMonte Carlo (B.
  Eslami-Mossallam et al.\, PLoS ONE (2016) 11\, e0156905)\, \nwe demonstra
 ted recently that the two information layers can be \nmultiplexed (as one 
 can have two phone conversations on the same wire). \nThis allows\, for in
 stance\, to guide on top of genes the packaging of DNA \ninto nucleosomes 
 with single base-pair precision. Genome wide studies of \nDNA mechanics fo
 r 50 different organisms taught us a simple general \nrule: around transcr
 iption start sites DNA is stiff for unicellular life \nand soft for multic
 ellular life. The reason for this difference is \nsurprising.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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