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SUMMARY:Evolutionary Genetics Journal Club - Speaker to be confirmed
DTSTART:20170717T150000Z
DTEND:20170717T160000Z
UID:TALK73821@talks.cam.ac.uk
CONTACT:Ruoyun Hui
DESCRIPTION:Casper Lumby is going to present the following paper:\nParalle
 l evolution of influenza across multiple spatiotemporal scales\nby Xue et 
 al.\n\nLink: https://elifesciences.org/articles/26875\n\nAbstract:\n\nVira
 l variants that arise in the global influenza population begin as de novo 
 mutations in single infected hosts\, but the evolutionary dynamics that tr
 ansform within-host variation to global genetic diversity are poorly under
 stood. Here\, we demonstrate that influenza evolution within infected huma
 ns recapitulates many evolutionary dynamics observed at the global scale. 
 We deep-sequence longitudinal samples from four immunocompromised patients
  with long-term H3N2 influenza infections. We find parallel evolution acro
 ss three scales: within individual patients\, in different patients in our
  study\, and in the global influenza population. In hemagglutinin\, a smal
 l set of mutations arises independently in multiple patients. These same m
 utations emerge repeatedly within single patients and compete with one ano
 ther\, providing a vivid clinical example of clonal interference. Many of 
 these recurrent within-host mutations also reach a high global frequency i
 n the decade following the patient infections. Our results demonstrate sur
 prising concordance in evolutionary dynamics across multiple spatiotempora
 l scales.\n
LOCATION:Bateson Room\, Department of Genetics\, Downing Site
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