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SUMMARY:Roles of miRNAs in animal development - Dr Eric Miska
DTSTART:20070606T153000Z
DTEND:20070606T163000Z
UID:TALK7449@talks.cam.ac.uk
CONTACT:6066
DESCRIPTION:MicroRNAs (miRNAs) are a large class of short non-coding RNAs 
 found in many plants and animals\, where they often act as post-transcript
 ional repressors of gene expression. Here we report the generation and ana
 lysis of loss-of-function mutations in almost all known microRNA genes in 
 C. elegans. Although we identify possible new roles for microRNAs in C. el
 egans embryogenesis and larval development\, we find that the majority of 
 microRNAs are not essential for development or viability of C. elegans. Mo
 reover\, whole microRNA families are not required for viability. This stud
 y represents the first comprehensive analysis of microRNA function in any 
 organism and provides a unique resource for the study of microRNAs.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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