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SUMMARY:Viral evolution on sub-phylogenetic timescales - Dr Chris Illingwo
 rth\, Department of Genetics\, University of Cambridge
DTSTART:20180215T140000Z
DTEND:20180215T150000Z
UID:TALK75491@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Genome sequencing has transformed our understanding of pathoge
 n evolution. Many pathogens evolve rapidly\, leaving behind genomic signat
 ures which\, when correctly understood\, provide valuable information abou
 t pathogen spread and adaptation.  However\, events such as within-host vi
 ral evolution and transmission pose a challenge for statistical analysis\;
  few genetic changes fix in the population\, such that there is little inf
 ormation available for phylogenetic methods to work on.  Here I describe h
 ow population genetic approaches can be combined with time-resolved sequen
 ce data to generate valuable insights into pathogen evolution.   By means 
 of example I discuss the cases of within-host reassortment in the influenz
 a virus and of strain specific immunity in the mouse malaria parasite Plas
 modium chaubaudi.
LOCATION:Part II Room\, Department of Genetics\, Downing Site
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