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SUMMARY:DNA methyltransferase(s)\, transposons and spermatogenesis - Dr D
 éborah Bourc'his\, Institut Curie\, Paris 
DTSTART:20180125T140000Z
DTEND:20180125T150000Z
UID:TALK75501@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:DNA methylation-based control of transposons is absolutely ess
 ential for the production of spermatozoa in mammals. In the mouse\, this f
 unction is dependent upon the newly discovered DNMT3C DNA methyltransferas
 e\, which has specifically evolved by tandem duplication of the DNMT3B gen
 e some 40 million years ago in the Muroidea lineagee. DNMT3C has the abili
 ty to selectively methylate the promoters of the most active transposons a
 nd only in the context of fetal spermatogenesis. As a key to understand th
 e basis of such specialization\, we will discuss our latest insights into 
 the evolution of DNMT3C and the dynamics of de novo methylation of young t
 ransposons sequences during male germ cell development. 
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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