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SUMMARY:LMB Seminar Series- How T cells control secretion to optimise targ
 et cell killing - Gillian Griffiths
DTSTART:20170919T100000Z
DTEND:20170919T110000Z
UID:TALK76031@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Killer cells of the immune system recognize and destroy virall
 y infected and cancer cells with remarkable precision. This is controlled 
 by a remarkable polarization within the killer cell once signaling is init
 iated upon recognition of a target to be killed.  The centrosome plays a k
 ey role\, docking directly at membrane of the synapse formed between kille
 r and target.  Our recent work has focused on the molecular changes in the
  plasma membrane that occur as the synapse forms\, and how these control b
 oth centrosome docking and secretion\, identifying a molecular sensor of T
  cell signaling that directly controls phosphoinositide specialization. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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