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SUMMARY:"A TREMendous mechanism for Alzheimer's Disease: therapeutic insig
 hts" - Dr Damian Crowther\, Neuroscience\, IMED Biotech Unit\, AstraZeneca
DTSTART:20171115T103000Z
DTEND:20171115T113000Z
UID:TALK94069@talks.cam.ac.uk
CONTACT:Patrick Flagmeier
DESCRIPTION:TREM2 is arguably the most potent genetic risk factor for spor
 adic Alzheimer's disease.  It is a scavenger receptor recognising generic 
 molecular patterns on cellular debris and amyloid fibrils.  Reduced levels
  of TREM2 on the surface of the brain's phagocytic cells\, the microglia\,
  is associated with disease risk.  Protecting TREM2 from proteolytic shedd
 ing from the microglial surface is a potential therapeutic goal.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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