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SUMMARY:Using Sidekick to Define the Role of Apical Vertices in Morphogene
 sis - Tara Finegan (Sanson lab\, PDN\, Cambridge)
DTSTART:20171213T173000Z
DTEND:20171213T193000Z
UID:TALK95452@talks.cam.ac.uk
CONTACT:Jelle van den Ameele
DESCRIPTION:During animal development\, epithelial tissues undergo morphog
 enesis in\norder to build tissues\, organs and body structure. A key drivi
 ng force in\nepithelial morphogenesis is cell rearrangement\, which result
 s from the\nremodelling of cell-cell contacts. In epithelia\, cell-cell co
 ntacts are\nconnected via vertices\, where 3 or more cells meet. I have us
 ed the\nDrosophila model to investigate the behaviour and role of vertices
  in\nepithelial morphogenesis\, using as an entry point a newly discovered
 \nmarker of epithelial vertices\, the Immunoglobulin-superfamily domain\np
 rotein Sidekick. Sidekick-YFP forms plaque-like structures at cell\nvertic
 es at the level of adherens junctions\, indicating that large\nmulti-prote
 in complexes containing Sidekick define a novel cortical domain\nin Drosop
 hila epithelia. Sidekick is the first protein in any organism\nfound to lo
 calise at vertices at the level of adherens junctions. Through\ncharacteri
 sation of a null allele of sidekick\, using both both manual and\nautomate
 d cell tracking based quantitative analysis\, I have found that\nSidekick 
 at apical vertices is important for the regulation of adhesion\,\ntissue g
 eometry and junction remodelling during morphogenesis of the\nembryonic ec
 toderm.
LOCATION:Gurdon Institute Tea Room
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