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SUMMARY:Mechanism of Rok planar polarisation at tissue boundaries during m
 orphogenesis - Clara Sidor
DTSTART:20171213T173000Z
DTEND:20171213T193000Z
UID:TALK95455@talks.cam.ac.uk
CONTACT:Jelle van den Ameele
DESCRIPTION:The MyosinII activator Rok (Rho associated kinase) is involved
  in a\nvariety of morphogenetic processes during embryonic development. In
 \nparticular\, Rok is planar polarised in a variety of tissues\, leading t
 o\nthe formation of Myosin cables. We are using the embryonic salivary gla
 nd\nformation as a morphogenetic model. In this tissue\, Rok is planar\npo
 larised at the boundary through a mechanism involving a negative\nregulati
 on by the apical polarity protein Crumbs (Crb) [1]. Using\nbiochemistry\, 
 imaging\, and a combination of modeling and FRAP experiments\,\nwe are exp
 loring the mechanism by which Crb and its intracellular partner\naPKC affe
 ct Rok membrane dynamics to trigger its polarisation. Moreover\,\nwe find 
 that Crb asymmetries together with Rok and Myosin cables happen at\nother 
 tissue boundaries\, indicating that this mechanism could be important\nin 
 other developmental contexts.\n
LOCATION:Gurdon Institute Tea Room
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