BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The glycobiology of antibodies\, Fc receptors and the immune respo
 nse - Jerrard Hayes
DTSTART:20180130T130000Z
DTEND:20180130T140000Z
UID:TALK95773@talks.cam.ac.uk
CONTACT:Tony Jackson
DESCRIPTION:ABSTRACT\nTherapeutic antibodies have had great success in can
 cer and autoimmune disease treatment and developments in antibody drug con
 jugates and bi-specifics continue to enhance patient treatment options. Im
 munoglobulin G antibodies are modified by the addition of conserved glycan
  chains to the antibody Fc region\, a modification critical for antibody i
 nteractions with the immune system and induction of effector activities su
 ch as complement activation\, phagocytosis and ADCC. Communication of IgG 
 antibodies with the immune system is controlled and mediated by Fc gamma r
 eceptors (FcγR)\, membrane bound glycoproteins that relay the information
  sensed and gathered by antibodies. These glycoprotein receptors act as a 
 link between the innate and adaptive immune systems and there is now clear
  evidence that FcγR glycosylation is also an important factor in the inte
 raction with antibodies and immune system activation or inhibition. Little
  is known\, however\, about how these receptors are glycosylated in their 
 natural environment by cells of the immune system\, in healthy and disease
  states. Through glycan analysis and sequencing we have shown that FcγR g
 lycosylation is complex\, differential depending on the receptor subtype a
 nd cell type specific. This has intriguing implications for how antibodies
  interact with cells of the immune system. Through biophysical interaction
  experiments we have shown that glycosylation of FcγRs is a critical comp
 onent of the antibody interaction and specific receptor glycoforms play a 
 key role to promote or inhibit a productive molecular engagement of antibo
 dy and receptor.  We believe this to be a mechanism used by the immune sys
 tem to fine-tune the antibody mediated immune response\, to enhance or inh
 ibit the interaction of antibodies and alterations in the balance of Fc ga
 mma receptor glycosylation can potentially lead to inflammation and autoim
 mune disease. 
LOCATION:Department of Biochemistry\, Sanger Building Jean Thomas Lecture 
 Theatre
END:VEVENT
END:VCALENDAR