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SUMMARY:Biophysical force regulation in cell migration - Mingming  Wu (Cor
 nell University)
DTSTART:20171214T150000Z
DTEND:20171214T163000Z
UID:TALK96808@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:In native states\, animal cells are surrounded by either fluid
  or a biopolymer network. The cell-environment interactions critically reg
 ulate cell function\, as well as collective cell motion. The key to this i
 nteraction is the biophysical forces that cells generate. In this talk\, I
  will focus on experimental studies of single cell force regulation in two
  biological systems. One is on tumor cell-extracellular matrix interaction
 \, in which we find that matrix mechanics\, and fluid flows together regul
 ate single tumor cell shape\, motility types and invasiveness. In the case
  of a group of tumor cells\, physical forces determine the formation or di
 ssociation of tumor spheroids. In a second example\, we studied how sperm 
 cells swim against fluid flows guided by a hydrodynamic force. Curiously\,
  in both cases\, biological matrices/fluids enhance force transmission ran
 ge and promote cell-cell interaction.<br><br><br><br>
LOCATION:Seminar Room 2\, Newton Institute
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