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SUMMARY:Computational Neuroscience Journal Club - Dhruva Raman (Control Gr
 oup)
DTSTART:20171212T160000Z
DTEND:20171212T170000Z
UID:TALK96874@talks.cam.ac.uk
CONTACT:Rodrigo Echeveste
DESCRIPTION:Dhruva Raman will cover:\n\n• Modular deconstruction reveals
  the dynamical and physical building blocks of a locomotion motor program.
 \n\n• Bruno AM\, Frost WN\, Humphries MD\n\n• Neuron (2015)\n\n• htt
 ps://www.ncbi.nlm.nih.gov/pubmed/25819612\n\nAbstract: The neural substrat
 es of motor programs are only well understood for small\, dedicated circui
 ts. Here we investigate how a motor program is constructed within a large 
 network. We imaged populations of neurons in the Aplysia pedal ganglion du
 ring execution of a locomotion motor program. We found that the program wa
 s built from a very small number of dynamical building blocks\, including 
 both neural ensembles and low-dimensional rotational dynamics. These map o
 nto physically discrete regions of the ganglion\, so that the motor progra
 m has a corresponding modular organization in both dynamical and physical 
 space. Using this dynamic map\, we identify the population potentially imp
 lementing the rhythmic pattern generator and find that its activity physic
 ally traces a looped trajectory\, recapitulating its low-dimensional rotat
 ional dynamics. Our results suggest that\, even in simple invertebrates\, 
 neural motor programs are implemented by large\, distributed networks cont
 aining multiple dynamical systems. \n
LOCATION:Cambridge University Engineering Department\, CBL\, BE4-38 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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