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SUMMARY:Mitotic Chromosome Condensation and Segregation - Dr Frank Uhlmann
 \, Cancer Research UK London Research Institute
DTSTART:20080219T181500Z
DTEND:20080219T190000Z
UID:TALK9768@talks.cam.ac.uk
CONTACT:Dr. Walid Khaled
DESCRIPTION:Mitotic chromosome structure depends on the chromosomal conden
 sin complex. Without condensin\, metaphase chromosomes remain undercondens
 ed and lack structural stability. This causes chromosome segregation defec
 ts during anaphase\, resulting in aneuploidy as seen associated with most 
 tumours. To understand the mechanism of chromosome condensation\, we have 
 asked where along budding yeast chromosomes the condensin complex associat
 es\, and what we can learn from its binding pattern. Our results suggest t
 hat condensin\, like its relative the cohesin complex\, is loaded onto chr
 omosomes by a loading factor\, the Scc2/4 complex. Unlike cohesin\, that m
 oves away from its loading sites after the loading reaction\, condensin re
 mains there in a dynamic equilibrium. The loading sites are characterised 
 by the RNA polymerase III transcription factor TFIIIC. These findings have
  important implications for both interphase and mitotic chromosome structu
 re.\n
LOCATION:Lecture Theatre\, Department of Pathology
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