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SUMMARY:Synthetic Cellularity via Protocell Design of Soft Matter Interfac
 es - Prof. Stephen Mann Centre for Protolife Research and Centre for Organ
 ized Matter Chemistry\, School of Chemistry\, University of Bristol\, Bris
 tol BS8 1TS\, UK
DTSTART:20180216T160000Z
DTEND:20180216T170000Z
UID:TALK98713@talks.cam.ac.uk
CONTACT:Lorenzo Di Michele
DESCRIPTION:*Abstract:*\nRecent progress in the chemical construction of m
 icro-compartmentalized colloidal objects comprising integrated biomimetic 
 functions is paving the way towards rudimentary forms of artificial cell-l
 ike entities (protocells) for modelling complex biological systems\, explo
 ring the origin of life\, and advancing future proto-living technologies. 
 Although several new types of protocells are currently available\, the des
 ign of synthetic protocell communities and investigation of their collecti
 ve properties has received little attention. In this talk\, I review some 
 recent experiments undertaken in my laboratory that demonstrate simple for
 ms of higher-order dynamic behaviour in synthetic protocells. I will discu
 ss four new areas of investigation: (i) Enzyme-powered motility and collec
 tive migration in buoyant organoclay/DNA protocells [1]\; (ii) artificial 
 predatory behaviour in mixed populations of proteinosomes and coacervate m
 icro-droplets [2]\; (iii) artificial phagocytosis behaviour in a binary po
 pulation of magnetic and silica colloidosomes [3]\, and (iv) chemical comm
 unication in ordered protocell communities [4]. I will use these new model
  systems to discuss pathways towards chemical cognition\, modulated reacti
 vity\, basic signalling pathways and non-equilibrium activation in compart
 mentalized artificial micro-ensembles.\n\n\n\n*References:*\n [1]	Kumar P\
 , Patil A J Mann S. Enzyme-powered motility in buoyant organoclay/DNA prot
 ocells. under review 119 (2017). \n[2] 	Qiao Y\, Li M\, Booth R and Mann S
 . Predatory behaviour in synthetic protocell communities. Nature Chemistry
  9\,110–119 (2017).\n[3]	Rodríguez-Arco L\, Li M and Mann S. Artificial
  phagocytosis in synthetic protocell communities of compartmentalized coll
 oidal objects. Nature Materials\, 16\, 857-863 (2017).\n[4] 	Tian L\, et.a
 l.\, Spontaneous assembly of chemically encoded two-dimensional coacervate
  droplet arrays by acoustic wave patterning. Nature Commun. 7\, 13068\, (2
 016)\n\n\n*Stephen Mann* is Professor of Chemistry at the University of Br
 istol UK and distinguished for contributions to biomineralization\, bioins
 pired materials chemistry and protocell research. Prof Mann was elected Fe
 llow of the Royal Society UK (2003)\, awarded the RSC de Gennes Prize (201
 1)\, SCF French-British Prize (2011) and Royal Society Davy Medal (2016)\,
  and was visiting professor at the College de France (2009) and Harvard Un
 iversity (2011). He has published over 500 scientific papers with a h inde
 x > 115.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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