Bobbie Claxton

Name:	Bobbie Claxton
Affiliation:	The Babraham Institute
E-mail:	(only provided to users who are logged into talks.cam)
Last login:	20 Oct 2025, 12:52 p.m.

Public lists managed by Bobbie Claxton

• Babraham Events
• Babraham Seminar
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Talks given by Bobbie Claxton

Obviously this only lists talks that are listed through talks.cam. Furthermore, this facility only works if the speaker's e-mail was specified in a talk. Most talks have not done this.

Talks organised by Bobbie Claxton

This list is based on what was entered into the 'organiser' field in a talk. It may not mean that Bobbie Claxton actually organised the talk, they may have been responsible only for entering the talk into the talks.cam system.

• Frontiers in Stem Cell Innovation
• Babraham Distinguished Seminar - Lipid switches in cell physiology: From nutrient signals to disease
• Degron peptides: Cancer mutation hotspots and tools for synthetic biology
• Cold temperature delays aging and proteostasis collapse
• Organismal Proteostasis: Collapse in Aging and Rejuvenation Approaches
• Evading ageing: Mitochondrial and proteostatic adaptations in oocytes
• Regrow with the flow: Mechanosensation in the regenerating zebrafish spinal cord
• Culturing Change: A Journey to Māori Equity in Biomedical Research
• Science publishing and publishing in Science
• Studying human oncoproteins beyond cancer: lessons learned from the RAS GTPases
• Epigenome Function: from molecular mechanisms to intergenerational inheritance
• Liquid–liquid phase separation in autophagy
• Activation-induced proteome re-modelling in B cells and the role of mTORC1
• Establishing a structure-function relationship between biomolecular condensates and protein degradation
• LGBTQ+ in Academia: Challenges and Prospects
• Selection Events in Germinal Centres
• Accounting for Carbon Emissions - Flows, scopes and data
• Is Resolution the End of Inflammation? Nope! There is more, lots more….
• How do autophagosomes form and grow?
• Genetic features controlling the specific expression of developmental genes
• The Tock Tick of Senescence
• Regulation of DNA repair by monoubiquitin signals
• Maintaining diversity while maximising affinity - IL-21 and the balancing act of B cell selection
• AMPK phosphorylation of FNIP1 dictates the kinetics of lysosome and mitochondrial biogenesis
• Collective T cell behaviour in health and disease
• Heterotypic Amyloid Interactions and their Impact on Amyloid Assembly
• Humoral immunity in the lung; spatiotemporal regulation of resident memory B cell responses to infection with influenza virus
• Using ‘omics to generate new insights into insulin-regulate glucose transport and insulin resistance & Don't drown your cells – considering oxygen tension in cell culture
• SARS-CoV-2 Variants
• RNA cap regulation in cell function and fate decisions
• Uncovering the role of regulatory T cells in tissue regeneration
• Targeting mitochondrial nucleotide metabolism in cancer
• Tuning of genome expression and energy metabolism during cellular proliferation, quiescence and ageing
• Early mammalian development and its regulation
• Blood-stage malaria vaccine development: the impact of vaccine platform and timing of booster dosing
• Proteotoxic stress, p53 and cell competition: mechanisms and impact on tissue colonisation
• Simple solutions to complex problems: from cell cycle regulation to anti-cancer treatments
• BYOB – Organising Appropriate Gatherings in the Lymph Node
• Towards a quantitative understanding of long-range transcriptional regulation
• Deciphering gene expression regulation in health and disease using integrative omics approaches
• FUS overexpression leads to cytoskeletal, organelle and cellular homeostasis perturbations
• The B cell receptor and beyond: specialized functions of the BCR in the intestine
• Targeting altered immune-crosstalk in tissues to enhance immunity
• Protein Kinase Regulation by the HSP90 Molecular Chaperone System
• This Is My Life, surviving academia as a Black woman in Britain
• Functional dissection of the genomic enhancer landscapes controlling pleiotropic gene expression and mammalian heart development
• A biophysical hypothesis for the initiation of spontaneous ALS
• My Life in Science Seminar: Determination in life, science and cells
• Phosphorylation-mediated signalling – a new era?
• Earth Day 2022 - How to save our planet: Developing win-win solutions
• Mitophagy: what, where, when and why
• Exploring PhoSfomes: from basic biology to drug discovery
• IWD 2022 - Bias in Science: an inspirational talk on bias mitigation
• Telling membranes where to go - the macroautophagy machinery in phagocytosis and viral envelope acquisition
• Transcriptional and post-transcriptional mechanisms of cell diversification - lessons from C. elegans
• Constructing 4D molecular roadmaps of cell fate decisions
• Colour within the lines – a personal perspective of navigating academia as a black woman
• Regulatory evolution by transcription-factor duplication
• A Tale of Two Phosphatases: The Control of Inflammation via Phosphorylation and Dephosphorylation of Tristetraprolin
• Title to be confirmed
• My Life in Science Webinar: Gut feelings
• Heavy mice and lighter things: developing models of extracellular matrix in health and ageing
• Secret Life of Copper: From Kinases to Cancer
• 3D genome folding, unfolding, and refolding in the mammalian brain
• L-selectin/CD62L: not just a lymph node homing receptor on T-cells
• Meet… Medicines Discovery Catapult
• Protein complexes subjected to tandem mass spectrometry reveal allosteric binding partners
• Research Ecosystems, Cognitive Bias and Incentives
• Ethical implications of ageing research
• Chromatin and Gene Transcription in Hypoxia
• Symmetry breaking and self-organization in intestinal organoids
• mTOR signaling in growth and metabolism
• The biology of CNS progenitor ageing
• The Rosalind Franklin Institute: Factor of 10 technologies
• The chromatin response of human cells to SARS-CoV-2 et al
• The biology of CNS progenitor ageing
• Reprogramming and plasticity of epigenetic regulation
• An institutional strategy to improve the trustworthiness, usefulness, and ethics of biomedical research
• Roles of TCR signal strength and duration in driving T cell development, differentiation and function
• Gender differences in question-asking at academic seminars
• Exercise-associated Neuroprotective Pathways in CNS Aging and Alzheimer’s Disease
• Title to be confirmed
• Innate immune cell decision making; understanding the mechanisms that trigger inflammation
• UK Autophagy Network seminar - “Molecular Mechanisms of Selective Autophagy”
• Quieting the Estrogen Receptor for Therapeutic Benefit in ER+ Breast Cancer
• Putting people before projects: Everything THAT nature communications paper got wrong about scientific success and mentorship
• Research integrity: strengthening research culture, research practice and research reproducibility
• Babraham Distinguished Lecture - Title to be confirmed
• Epigenetic regulation, heterochromatin and anti-fungal resistance
• The Climate crisis and its solutions - what role can scientists play?
• Senescence Lifecycle in cancer and ageing
• Success: what lies behind the mask?
• Native ambient mass spectrometry: Latest developments for in situ protein analysis
• CRISPR Tools for Functional Genomics and Disease Models
• How can academic centres perform Covid testing? Lessons from the Crick Institute
• Explorations of N- and O-linked Glycosylation on Extracellular and Intracellular Cell Surfaces
• The Cambridge Bioinformatics Hackathon 2020
• Strategies to target senescence
• Translating the Hypoxic Response – Role of Preferential Protein Translation in Cellular Response to Low Oxygen
• The protein kinase DYRK2 as a new regulator of protein homeostasis
• Ying and Yang of G-quadruplxes for genome stability
• Supramolecular arsenal of adaptive and natural killers
• Profiling and understanding Ras variant biology
• RAC1 mutations in human neurodevelopmental disorders
• Questions around cellular plasticity: naive pluripotency and epigenetic rejuvenation by reprogramming
• Building industrial academic collaborations; managing the relationship
• The Senescence-Associated Innate Immune Sensors in Tumour Suppression
• Title to be confirmed
• Germinal centres and plasma cells - regulating the beginning and the end of the B cell response to antigen
• Circular RNAs and their molecular roles in myogenesis and in rhabdomyosarcoma
• Babraham Distinguished Lecture - "Switching Genes on and Off in Haematopoiesis"
• Title to be confirmed
• Title to be confirmed
• Babraham Distinguished Lecture - Title to be confirmed
• Lister Prize winning Lecture - Remodelling the lung to host unconventional germinal centres
• Babraham Distinguished Lecture - Genome regulation during developmental transitions: New views of old questions
• DNA-embedded ribonucleotides: from mechanistic insights to therapeutic opportunities
• Adult hippocampal neurogenesis in health and disease
• Babraham Distinguished Lecture - "Mass Spectrometry - from plasma proteins to mitochondrial membranes"
• The enigma of histone 3 lysine 4 methylation
• Metabolic control of T cell function
• Babraham Distinguished Lecture - Different mechanisms define lncRNA and protein coding gene transcription units in mammalian cells
• Transcription factors as sensors and modifiers of chromatin
• EU Life Lecture - Spontaneous protein crystallization as a driver of immunity
• Babraham Distinguished Lecture - Antisense-mediated chromatin silencing
• Immunometabolims taught by patients
• Targeting GARP on human Tregs: a novel approach for the immunotherapy of cancer?
• Regulating gene expression in 3D: a view from Drosophila embryogenesis
• “iPS Proteomes in Health and Disease"
• How chromatin is spatially reorganised during zygotic reprogramming to totipotency
• My Life in Science Seminar
• The phospholipid PI(3,4)P2 is an apical identity determinant
• The phospholipid PI(3,4)P2 is an apical identity determinant
• MHC-independent thymocyte selection, is it possible?
• High-Throughput Production of Human Proteins for Structural and Functional Studies
• A rate-limiting process: T cell activation from a single-cell perspective
• scSLAM-seq and GRAND-SLAM reveal core features of the intrinsic immune response in single virus-infected cells
• All kinds of JNK: How one kinase can be an oncogene, tumour suppressor and apoptotic mediator
• Procollagen quality control at ER exit sites
• Lipid code for phosphatidylinositol bisphosphate synthesis
• An integrative systems genetic analysis of mammalian lipid metabolism
• The regulation and consequences of immune responses during Salmonella infections
• Regulation of B cell responses by distinct populations of T cells
• Babraham Distinguished Lecture - "Control of B cell immunity and leukemia by the transcription factor Pax5"
• Iron powers adaptive immunity
• My Life in Science Seminar - In a straight line - with a few bends
• Babraham Distinguished Lecture - Understanding cellular dynamics in mammalian skin
• Developmental lineage mapping by genomic barcoding in the mouse
• Nucleosomal Asymmetry Shapes Histone Mark Binding at Bivalent Domains
• Proteomic analysis of cell state transitions
• Babraham Distinguished Lecture - Selective autophagy receptors and LIR-ATG8 interactions in autophagy
• Genetic analysis of a conserved protein reveals an important role in Plasmodium falciparum merozoite invasion of the host red blood cell
• Immune disease GWAS variants converge on regulation of cd4 T cell activation
• Precision metagenomic analysis in personalised medicine and birth cohort studies
• Liver Lipid Metabolism and Healthy Ageing: Themes from the Drug Discovery Frontline
• Babraham Distinguished Lecture - Elucidating new ways to target downstream of KRAS mutation in colorectal cancer : metabolic and microenvironment targets
• Babraham Distinguished Lecture - "Regulating p53 and beyond: from cell death to sudden death"
• The phospholipid PI(3,4)P2 is an apical identity determinant
• Dynamics of hematopoietic stem and progenitor cell differentiation in vivo
• Rewiring of mTORC1-autophagy pathways in senescence and melanoma
• Male germline epigenetic priming for future development
• Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis
• Babraham Distinguished Lecture - MeCP2 and the causes of Rett syndrome
• HuR vs. TTP: Who is really the Master Regulator of CD4+ T cell Differentiation?
• EU Life Lecture - Temporal scaling of C. elegans Ageing
• Neutrophils in the regulation of inflammation
• Chromatin binding proteins in pluripotent stem cells :Insights from single-cell Hi-C and single-molecule imaging
• Modelling the pathological long-range regulatory effects of structural variation with patient-specific hiPSC
• Food allergen-sensitized CCR9+ lymphocytes enhance airways allergic inflammation in mice
• Babraham Distinguished Lecture - Endoplasmic reticulum turnover via selective autophagy
• Molecular mechanisms of chromosome folding
• Precision metagenomic analysis in personalised medicine and birth cohort studies
• Babraham Lecture - Controlling the killers: from genes to membranes
• Lister Prize Lecture - "Molecular mechanisms of immunological tolerance and immunosuppression"
• Cell immortalisation strategies past and present
• Including sex and gender in (bio)medical research design
• Visualization of low-level Gene Expression and Biomarker Localization within Tissue: Applications of RNAscope® and BaseScope
• PI3K delta-RAC2 axis controls phagosomal NADPH oxidase activity in dendritic cells and maintains gut immunity and tolerance
• Title to be confirmed
• Babraham Lecture - Cellular responses to DNA damage: from mechanistic insights to applications in cancer therapy
• Drosophila Kinome and Genome-wide RNAi screens reveal novel regulators of epigenetic cell memory
• Post-transcriptional gene dysregulation in human asthma as determined by Frac-seq.
• Polymer Modelling of the 4D Epigenome
• Bisulfite-free, Base-resolution, and Quantitative Sequencing of Cytosine Modifications
• Babraham Lecture - Pathology from the Molecular Scale on Up
• OH! The places you’ll go: Protein hydroxylation and its role in physiology and disease
• Computational modeling of the CD8 T cell immune response: How mathematical models can provide insights on differentiation and heterogeneity?
• Viral Vectored Vaccines against Influenza
• Babraham Lecture - Ras proteins as therapeutics targets
• Investigations into the formation and re-activation of memory B cells
• Agilent Genomics - Lunch & Learn Seminar
• Epigenetic regulation of antibody production and the formation of B cell memory to acute and chronic infections
• Babraham Lecture - The Remote Control of Gene Expression
• My Life in Science Seminar “Publishing in Science: an Inside Look"
• The Regulation of DNA Methylation in Mammalian Development and Cancer
• Hypothalamic control of body weight: the role of protein degradation systems in a high-fat diet-induced obesity model
• How cells regulate the dynamics of chromatin patterns
• The DNA oxygenase TET1 in mammalian embryonic development and epigenetic reprogramming
• Babraham Lecture - Understanding how the p53 onco-suppressor gene works: hints from the P2X7 ATP receptor
• Spatial Positioning of Innate Cells Controls B Cell Immunity to Infection
• Cellular recycling: role of autophagy in aging and disease
• Identifying new gene regulating networks in immune cells
• Optical control of T-cell signalling dynamics
• Babraham Lecture - Deciphering the gene regulation network in human germline cells at single-cell & single base resolution
• Genome-wide analysis of protein-DNA interactions
• Semantic Data Integration and Knowledge Management in Life Sciences
• Transcriptional control of pluripotent stem cell fate by the Nucleosome Remodelling and Deacetylation (NuRD) complex
• "Chronic Inflammatory Diseases and Tryptophan Catabolism"
• "Vectorbuilder: Revolutionising Vector Design & Custom Cloning" (25 min seminar) followed by "Advanced Technologies For Rapid Generation Of Custom Designed Animal Models" (25 min seminar)
• Interrogating T cell signalling and effector function in hypoxic environments
• “Dissecting mutation patterns in human stem cells to study processes that cause cancer”
• My Life in Science Seminar
• "RNA modifications as regulators of stem cell function"
• "Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity"
• "Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity"
• "LARP1 a post-transcriptional driver of cancer gene expression"
• "Post-transcriptional regulation dictates T cell functionality in health and disease"
• "Post-transcriptional regulation dictates T cell functionality in health and disease"
• "SMUG1 - A Classical DNA Glycosylase And An RNA Processing Enzyme"
• "Quantitative 3D-SIM imaging of chromatin domain organisation"
• EU LIFE Lecture - "Histone Chaperones Maintain Cell Fates and Antagonize Reprogramming in C. elegans and Human Cells"
• "Mechanosensitive regulation of cancer epigenetics and pluripotency"
• "Live cell biochemistry by light"
• Title to be confirmed
• "miR-221 promotes precursor B-cell retention in bone marrow by amplifying the Pi3K-signaling pathway"
• “In vivo and in vitro imaging of leukocyte responses during inflammation”
• “Meis2 activation by Kdm2b-containing complexes”
• “Symmetry breaking and self-organisation in mouse development”
• "Generic patterns of clone dynamics in growing tissues"
• Studying long-distance enhancers of Sox9 in the developing mouse gonad
• "The roles of alternative splicing in regulating the function of intrinsically disordered regions"
• “Modulating Tregs in Cancer and Autoimmunity”
• EU LIFE Lecture - Title to be confirmed
• EU LIFE Lecture - Title to be confirmed
• “Map plasticity and synthetic lethality in oncogenic PI3K signals with T cell leukemia”
• "The Circadian Clockwork and Innate Immunity"
• "Pioneer Transcription factors in programming and reprogramming"
• EU Life Lecture - “Rembrandt: Remodelling the brain in intellectual disability”
• Equality4Success - "My life in science seminar"
• Equality4Success - "My life in science seminar"
• “Targetting Tribbles 2 pseudokinase with drugs”
• “Structural maintenance of chromosome complexes differentially compact mitotic chromosomes according to genomic context”
• Athena SWAN - My Life in Science Seminar - "An alternative route to an independent research career"
• EU Life Lecture - “The interplay between neuronal activity and actin dynamics in synaptic tagging and capture”
• “Creating New In-Roads for Cancer-Specific T Cells”
• "Group 2 Innate Lymphoid cells at the interface between innate and adaptive immunity"
• "Regulatory feedback from nascent RNA to chromatin"
• EU Life Lecture - "Genomic approaches to study chromosome architecture and function"
• "Defining the relationship between stem and progenitor cells in the intestinal epithelium"
• "RhoGEFs as signaling platforms of chemotactic GPCRs"
• "Regulation of X-chromosome inactivation in human development"
• “Editing the genome of human induced pluripotent stem cells”
• "Investigating the mechanisms of regulatory T-cell differentiation in vivo by novel Fluorescent Timer reporters"
• Title to be confirmed
• Athena SWAN - My Life in science Seminar "There’s more to academia than research, you know"
• "Practical Applications of Analysing the Antibody Repertoire"