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Quantifying neuronal loss in frontotemporal dementia – studying the human brain at post mortem

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If you have a question about this talk, please contact Janet Gibson.

Frontotemporal dementia (FTD) is a severe and incurable neurodegenerative disease associated with loss of neurons in frontal and temporal cortices, and abnormal deposition of misfolded and aggregated proteins. Although the molecular mechanisms underlying FTD are heterogeneous, the illness is striking in the specificity of neurodegeneration to layer II and V of the cortex. This creates the opportunity to study how protein inclusions perturb neuronal networks, and how the pathological specificity at post mortem microscopy may improve ante mortem brain imaging for early diagnosis and tracking of disease progression. Using a set of mathematical and statistically methods, called stereology, I am measuring the burden of protein pathology and numbers of brain cells in FTD .

This talk is part of the Darwin College Science Seminars series.

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