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Matteo Molรจ
Monday 24 May 2021, 14:30-15:30
Morphogenesis of the mouse and human embryo beyond implantation
- ๐ค Speaker: Matteo Molรจ
- ๐ Date & Time: Monday 24 May 2021, 14:30 - 15:30
- ๐ Venue: Online
Abstract
During the transition from pre-implantation to early post-implantation the mammalian embryo undergoes major morphogenetic changes, leading to transformation of the blastocyst into the egg-cylinder or bilaminar disk configuration, in mouse or human respectively. We found that integrin ๏ข1 is required during this transition, coordinating morphogenesis and promoting survival of the embryo proper. By single cell RNAseq, we also characterised a sequence of events underlying post-implantation development of the human embryo. We identified a group of cells which may act as an evolutionary-conserved anteriorising signalling centre for the establishment of the anterior-posterior axis prior to gastrulation.
Series This talk is part of the Morphogenesis Seminar Series series.
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