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Frank Ernesto Alvarez Borges (Université Paris-Dauphine)
Tuesday 03 May 2022, 14:50-15:35
Modelling bet-hedging: A link between cancer and the emergence of multicellularity
- 👤 Speaker: Frank Ernesto Alvarez Borges (Université Paris-Dauphine)
- 📅 Date & Time: Tuesday 03 May 2022, 14:50 - 15:35
- 📍 Venue: Seminar Room 2, Newton Institute
Abstract
Confronted with the biological problem of managing plasticity in cell populations, which is in particular responsible for transient and reversible drug resistance in cancer, we propose a rationale consisting of an integro-differential and a reaction-advection-diffusion equation, the properties of which are studied theoretically and numerically. By using a constructive finite volume method, we show the existence and uniqueness of a weak solution and illustrate by numerical approximations and their simulations the capacity of the model to exhibit divergence of traits. This feature may be theoretically interpreted as describing a physiological step towards multicellularity in animal evolution and, closer to present-day clinical challenges in oncology, as a possible representation of bet hedging in cancer cell populations.
Series This talk is part of the Isaac Newton Institute Seminar Series series.
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