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RNA Controls DNA in the Human Cell Nucleus

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Transcription factors, histone methyltransferases, DNA methyltransferases, CTCF , and RNA pol II – which must necessarily bind chromatin – also bind RNA . In many cases, the RNA and DNA binding sites overlap enough that their binding is mutually antagonistic. We have determined the cryo-EM structure of Polycomb Repressive Complex 2 (PRC2) bound to RNA , which gives unexpected insights regarding the mechanism of RNA inhibition. Furthermore, we find that PRC2 and other DNA - and RNA -binding proteins can be directly transferred or “handed off” between nucleic acid ligands without a free protein intermediate. Such direct transfer may be necessary for these proteins to find their cognate binding sites in cells and may be a prerequisite for biological condensates to facilitate recruitment of proteins to chromatin.

This talk is part of the Biochemistry Seminar Series - External Speakers series.

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