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Embryo-scale reverse genetics at single cell resolution reveals lineage-specific modules underlying cranial development

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If you have a question about this talk, please contact Caroline Newnham .

Host - Ben Steventon

The Saunders lab is interested in understanding the interplay between a cell’s developmental history, function, and its flexibility to change. We use zebrafish as a model system to explore the limits of cell fate specification. By combining scalable single cell RNA -sequencing methods, lineage tracing, and genetic tools, we aim to study these complex developmental processes at multiple scales (molecular, cellular, organismal). We leverage single-animal barcoding strategies to enable quantification of molecular and cellular phenotypes in whole developing embryos, with the ultimate goal of understanding how animals overcome genetic and environmental perturbations and how this underlies morphological evolution.

This talk is part of the Genetics Seminar series.

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