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Reini Luco, National Cancer Institute, National Institutes of Health, Bethesda
Friday 02 April 2010, 14:00-15:00
Regulation of Alternative Splicing by Histone Modifications
- 👤 Speaker: Reini Luco, National Cancer Institute, National Institutes of Health, Bethesda
- 📅 Date & Time: Friday 02 April 2010, 14:00 - 15:00
- 📍 Venue: Cancer Research UK Cambridge Research Institute, Room 215
Abstract
Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.
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